Life Sciences

  • Data tools give microscopes unprecedented views of living and physical systems

    Wednesday, Aug 8, 2018
    by Steven Schultz, Office of Engineering Communications

    Techniques and tools for seeing fleeting arrangements of atoms during chemical reactions are advancing rapidly, allowing unprecedented insights into physical and living systems, according to experts in microscopy from around the world who gathered for a three-day conference at Princeton in July.

  • MacMillan lab finds new way to bond molecules that could speed drug discovery

    Monday, Aug 6, 2018
    by by Amy Carleton

    Bringing new drugs to market takes time. Laboratory testing, clinical research and U.S. Food and Drug Administration review — and all the steps in between — add up to 17 years, on average, for research evidence to reach clinical practice.

    But what if organic chemists could speed up that process by providing medicinal chemists with new tools that would facilitate selective molecule activation to support drug discovery?

  • Researchers apply computing power to track the spread of cancer

    Tuesday, Jul 3, 2018
    by Molly Sharlach, Office of Engineering Communications

    Princeton researchers have developed a new computational method that increases the ability to track the spread of cancer cells from one part of the body to another.

    This migration of cells can lead to metastatic disease, which causes about 90 percent of cancer deaths from solid tumors — masses of cells that grow in organs such as the breast, prostate or colon. Understanding the drivers of metastasis could lead to new treatments aimed at blocking the process of cancer spreading through the body.

  • Timing is key for bacteria surviving antibiotics

    Monday, Jul 2, 2018
    by Molly Sharlach, Office of Engineering Communications

    For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment.

    When antibiotics hit a population of bacteria, often a small fraction of “persister” cells survive to pose a threat of recurrent infection. Unlike bacteria with genetic resistance to antibiotics, evidence suggests that persisters stay alive in part by stalling cellular processes targeted by the drugs.

  • Immune cell provides cradle for mammary stem cells

    Thursday, May 17, 2018
    by Catherine Zandonella, Office of the Dean for Research

    A new study finds that one of the toughest characters in the immune system, the macrophage, has a nurturing side, at least when it comes to guarding the developing breast.

    The study published online this week in the journal Science found that macrophages play an important role in maintaining the mammary gland's stem cell niche, a sort of nursery for the precursors of milk-producing cells in the breast.

  • Petry finds missing ingredient to spark the fireworks of life

    Wednesday, May 16, 2018
    by Liz Fuller-Wright, Office of Communications

    Most people can name at least a few bones of the human body, but not many know about the cytoskeleton within our cells, let alone the “microtubules” that give it its shape. Now, a group of Princeton researchers has resolved a long-standing controversy by identifying exactly how the body creates these micron-sized filaments.

  • Princeton Research Day puts spotlight on innovative work across University

    Monday, May 14, 2018
    by Princeton University

    Spend the day — or an hour — at Princeton Research Day, and you get an eclectic tour of research at Princeton University shared through presentations designed to make cutting-edge work accessible to the general public.

    For Sarah-Jane Leslie, dean of the Graduate School and the Class of 1943 Professor of Philosophy, that tour included learning how engineers can learn lessons from plants; about new techniques to fight disease; and about novel ways to address the world’s energy crisis.

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