Techniques and tools for seeing fleeting arrangements of atoms during chemical reactions are advancing rapidly, allowing unprecedented insights into physical and living systems, according to experts in microscopy from around the world who gathered for a three-day conference at Princeton in July.
- Wednesday, Aug 8, 2018
- Monday, Aug 6, 2018
Bringing new drugs to market takes time. Laboratory testing, clinical research and U.S. Food and Drug Administration review — and all the steps in between — add up to 17 years, on average, for research evidence to reach clinical practice.
But what if organic chemists could speed up that process by providing medicinal chemists with new tools that would facilitate selective molecule activation to support drug discovery?
- Tuesday, Jul 3, 2018
Princeton researchers have developed a new computational method that increases the ability to track the spread of cancer cells from one part of the body to another.
This migration of cells can lead to metastatic disease, which causes about 90 percent of cancer deaths from solid tumors — masses of cells that grow in organs such as the breast, prostate or colon. Understanding the drivers of metastasis could lead to new treatments aimed at blocking the process of cancer spreading through the body.
- Monday, Jul 2, 2018
For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment.
When antibiotics hit a population of bacteria, often a small fraction of “persister” cells survive to pose a threat of recurrent infection. Unlike bacteria with genetic resistance to antibiotics, evidence suggests that persisters stay alive in part by stalling cellular processes targeted by the drugs.
- Thursday, May 17, 2018
A new study finds that one of the toughest characters in the immune system, the macrophage, has a nurturing side, at least when it comes to guarding the developing breast.
The study published online this week in the journal Science found that macrophages play an important role in maintaining the mammary gland's stem cell niche, a sort of nursery for the precursors of milk-producing cells in the breast.
- Thursday, May 17, 2018
With the help of a quarter-million video game players, Princeton researchers have created and shared detailed maps of more than 1,000 neurons — and they’re just getting started.
- Wednesday, May 16, 2018
Most people can name at least a few bones of the human body, but not many know about the cytoskeleton within our cells, let alone the “microtubules” that give it its shape. Now, a group of Princeton researchers has resolved a long-standing controversy by identifying exactly how the body creates these micron-sized filaments.
- Monday, May 14, 2018
Spend the day — or an hour — at Princeton Research Day, and you get an eclectic tour of research at Princeton University shared through presentations designed to make cutting-edge work accessible to the general public.
For Sarah-Jane Leslie, dean of the Graduate School and the Class of 1943 Professor of Philosophy, that tour included learning how engineers can learn lessons from plants; about new techniques to fight disease; and about novel ways to address the world’s energy crisis.
- Tuesday, Jul 24, 2018
Princeton chemist Gregory Scholes has been awarded $1,000,000 by the W.M. Keck Foundation to investigate harnessing the wave basis of quantum mechanics to drive chemical reactions.
If successful, this breakthrough will suggest possibilities for understanding and controlling biochemical reactions.
- Thursday, Apr 26, 2018
In April 2018, Dean for Research Pablo Debenedetti was interviewed by the on-campus newspaper, The Daily Princetonian, on research collaborations between Princeton and companies in the life sciences. The article provides a round-up of current activities and reflects student interest in engagement with industry.