Oral and gut microbes can inactivate an antidiabetic drug, Princeton scientists find

Acarbose is a commonly prescribed antidiabetic drug that helps control blood sugar levels by inhibiting human enzymes that break down complex carbohydrates. Now, new research from the laboratory of Princeton researcher Mohamed Donia demonstrates that some bacteria in the mouth and gut can inactivate acarbose and potentially affect the clinical performance of the drug and its impact on bacterial members of the human microbiome.