Save the Date: Join us for the Third Annual Regional Academic Drug Discovery Conference
More than 200 stakeholders in drug discovery from industry, academia and government will come together on the Princeton University campus for a full day of programming. (Check out the program at last year's event hosted by Rutgers.)
2019 Keynote
Barry R. O'Keefe, Ph.D.
Acting Chief, Molecular Targets Program
Center for Cancer Research
Chief, Natural Products Branch, Developmental Therapeutics Program
Division of Cancer Treatment and Diagnosis
National Cancer Institute
Natural Product-based Drug Discovery: Why, How and Is Now the Time?
Natural products have a proven track record in use as anti-cancer and anti-infective agents. As of 2014 natural products (NP), NP pharmacophores, and NP mimics represented more than 50 percent of small molecule-based anti-cancer and anti-microbial drugs. However, accessing the potential of NPs in high-throughput screening (HTS) campaigns has been challenging due to the complexity of the crude NP extracts, the time necessary for follow-up isolation efforts, and indefinite capabilities for large-scale resupply. This has resulted in NP-based libraries being significantly underrepresented in most recent large-scale HTS programs.
The US National Cancer Institute’s Natural Product Extract Repository is one of the world’s largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine and microbial organisms. To address the challenges in screening NPs and encourage increased assay of NP chemical diversity, we have initiated the NCI Program for Natural Product Discovery (NPNPD) which has developed an automated, high-throughput robotics platform capable of generating a library of >1,000,000 partially purified extracts for screening. In addition, automated secondary purification and structure elucidation platforms have been created that significantly decrease costs and timelines. This presentation will discuss the reasons for, challenges to, and mechanisms by which to increase the pace and efficiency of NP-based drug discovery.
November 1, 2019, 8am-5pm
McDonnell Hall, Princeton University
New Jersey Academic Drug Discovery Consortium.
Hosted by
Sponsorship Opportunities
Dean Edelman, dean.edelman@princeton.edu, 609-258-6214
Laurie Tzodikov, tzodikov@princeton.edu, 609-258-7256
Call for Abstracts of Presentations
Deadline to submit an presentation abstract for consideration: September 20, 2019.
Submission guidelines and form are found here.
Poster Reservations and Information
Deadline to submit a poster abstract for consideration: October 15, 2019.
Submission guidelines and form are found here.
Maximum poster size: 4' x 4'
For more information, contact Troy Messick, tmessick@wistar.org
Attendee Information
Hotel and Transportation Information
Travel and lodging info for visitors to the Princeton campus
Lodging info from VisitPrinceton.org, the Princeton Mercer Convention & Visitors Bureau
There are no negotiated discounts for travel or lodging related to this conference.
Ticketing Information
Please complete this form to receive more information and an invitation to attend when tickets are available.