Core Facilities

Princeton University offers numerous top-of-the-line scientific research facilities that welcome external users. Each facility has its own fee structure and participation requirements. Users must demonstrate familiarity with the specialized equipment before independent use is allowed; however, training by staff members is available.

Confocal Microscopy Facility (includes Nikon Center of Excellence) Provides laser scanning confocal microscopy and super resolution microscopy (structured illumination and localization types), which offer the highest light microscope resolution obtainable. This technology can image single or multiple labeled specimens and can be used to study intact samples, such as developing fish embryos or sections from brain and other tissues that have been tagged with fluorescent probes.

Flow Cytometry Resource Facility: Provides equipment, training, and support for flow cytometry and cell sorting (FACS); and handles a wide variety of cell types, including human, murine, porcine and insect cell lines, as well as primary murine leukocytes, stem cells, bacteria, yeast, C. elegans , and seawater samples. Staff members can assist in experimental design, sample preparation, data acquisition, analysis and interpretation, publications, and grant-related activities. This facility is affiliated with the Rutgers Cancer Institute of New Jersey. 

Genomics Core Facility: Houses state-of-the-art, high-throughput sequencing technologies; is fully equipped for all aspects of microarray labeling, hybridization, and data acquisition; and offers sequencing library preparation services, consultation on experimental design, and data analysis. Collaborations on developing novel sequencing applications are also welcome. This facility works closely with the Research Computing Staff to provide computing power and consulting services to analyze the Sequencing and Microarray data. 

Imaging and Analysis Center (IAC):  Offers high-end, state-of-the-art instrumentation and expertise for characterization of both hard and soft (including biological) materials for research and education. It is one of the most advanced materials characterization facilities in the world and is utilized by numerous departments across campus. IAC also collaborates with researchers in industry and other academic institutes. The IAC boasts a suite of Princeton University’s consolidated transmission (TEM) and scanning electron microscopes (SEM) that include both the premiere echelon hard materials TEM capable of resolving individual atoms and life science cryo-TEM used to reconstruct 3D atomic resolution protein structures. When combined with micro/nano chemical, thermal and structural analysis capabilities, a dual-beam focused ion beam system for materials manipulation, atomic force microscopes, X-ray diffractometers, 3D X-ray microscope, XPS/UPS, computer simulation and image processing capabilities, as well as materials preparation facilities, IAC has an unparalleled breadth and depth of imaging and analysis capabilities.

Macromolecular Crystallography Core Facility: Offers researchers the most effective tool for understanding macromolecular structure. Staff can assist with setting up crystallization trials, x-ray data collection for both macromolecular and small-molecule samples, structure determination and analysis, interpretation of existing structures available in the Protein Data Bank, and homology modeling. 

Micro/Nano Fabrication Laboratory: Provides facilities and equipment for working with a variety of materials to fabricate devices and structures for electronics, photonics, micro-electro mechanical systems (MEMS) and biological applications. The 5,000-foot clean room includes facilities for thin-film formation, pattern transfer by plasma etching, and optical, nano-imprint and electron beam lithography. 

Nuclear Magnetic Resonance Facility: Offers access to state-of-the-art equipment for probing the structural and chemical properties of molecules, as well as a variety of software tools for data processing and analysis. The facility houses seven NMR spectrometers including instruments featuring robotic liquid handlers and large capacity auto-samplers for high-efficiency small molecule studies. 

Proteomics and Mass Spectrometry Center: Offers a range of services and collaborative opportunities for large and small-scale projects in mass spectrometry-based biological research. The Center serves as a scientific partner in activities ranging from project design to sample preparation, MS data acquisition and analysis, write-up, dissemination, and grant-related activities. The Center is equipped with state-of-the-art MS instrumentation. 

 

 

 

FEI Titan Cubed Themis 300 double Cs-corrected Scanning/Transmission Electron Microscope (S/TEM) in the Imaging and Analysis Center

Bruker D8 Discover X-Ray Diffractometer in the Imaging and Analysis Center

Bruker D8 Discover X-Ray Diffractometer in the Imaging and Analysis Center